By Ion Mandoiu, Alexander Zelikovsky
Offers algorithmic recommendations for fixing difficulties in bioinformatics, together with functions that shed new gentle on molecular biology
This ebook introduces algorithmic recommendations in bioinformatics, emphasizing their software to fixing novel difficulties in post-genomic molecular biology. starting with a thought-provoking dialogue at the function of algorithms in twenty-first-century bioinformatics schooling, Bioinformatics Algorithms covers:
General algorithmic thoughts, together with dynamic programming, graph-theoretical tools, hidden Markov types, the short Fourier rework, seeding, and approximation algorithms
Algorithms and instruments for genome and series research, together with formal and approximate types for gene clusters, complex algorithms for non-overlapping neighborhood alignments and genome tilings, multiplex PCR primer set choice, and sequence/network motif finding
Microarray layout and research, together with algorithms for microarray actual layout, lacking price imputation, and meta-analysis of gene expression data
Algorithmic matters bobbing up within the research of genetic edition throughout human inhabitants, together with computational inference of haplotypes from genotype facts and illness organization seek in case/control epidemiologic studies
Algorithmic techniques in structural and structures biology, together with topological and structural class in biochemistry, and prediction of protein-protein and domain-domain interactions
Each bankruptcy starts with a self-contained advent to a computational challenge; maintains with a quick overview of the prevailing literature at the topic and an in-depth description of modern algorithmic and methodological advancements; and concludes with a quick experimental learn and a dialogue of open study demanding situations. This transparent and approachable presentation makes the e-book applicable for researchers, practitioners, and graduate scholars alike.
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