Download E-books Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine PDF

By Ephraim Yavin, Annette Brand (auth.), Mark P. Mattson (eds.)

Lipid rafts-discrete areas in telephone membranes which are wealthy in ldl cholesterol and sphingolipids-are rising not just as pivotal command and keep watch over facilities for mobile signaling procedures, but additionally as relevant to a big selection of human illnesses, together with immune problems, diabetes, heart problems, and Alzheimer's illness. In Membrane Microdomain Signaling: Lipid Rafts in Biology and medication, multidisciplinary specialists supply state-of-the-art experiences of our present figuring out of those membrane microdomains and their physiological and pathological roles. the following, readers will notice how lipid rafts swap in cells over the years and the way they reply to quite a few environmental signs, how ldl cholesterol modulates the signaling functionality of lipid rafts, and the way lipid rafts, the extracellular matrix, and the phone cytoskeleton structurally engage. additionally defined are the position of lipid rafts in studying, reminiscence, and melanoma, and as portals for endocytic uptake of an anticancer- and apoptotic alkyl-lysophospholipid. The authors additionally current rising facts that lipid rafts play severe roles in signaling pathways and the rules of synaptic functionality within the apprehensive approach, and that changes in lipid raft metabolism are implicated within the pathogenesis of neurodegenerative issues. in addition they describe ideas for the isolation of lipid rafts, the research of the lipid and protein parts of lipid rafts, the imaging of lipid rafts in residing cells, and the research of sign transduction in lipid rafts.
entire and insightful, Membrane Microdomain Signaling: Lipid Rafts in Biology and medication deals researchers a multidisciplinary evaluate of the newest easy, translational, and scientific examine that offers to remodel our knowing microdomain signaling mechanisms.

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