By Stuart M. Brown
Next-generation DNA sequencing (NGS) know-how has revolutionized biomedical learn, making genome and RNA sequencing a cheap and regularly used device for a wide selection of analysis functions together with version (mutation) discovery, gene expression, transcription issue research, metagenomics, and epigenetics. Bioinformatics easy methods to help DNA sequencing became and stay a serious bottleneck for lots of researchers and corporations wishing to use NGS know-how. This re-creation presents a radical, plain-language advent to the required informatics equipment and instruments for examining NGS information and gives unique descriptions of algorithms, strengths and weaknesses of particular instruments, pitfalls, and substitute tools. 4 new chapters hide experimental layout, pattern instruction, and caliber review of NGS info; public databases for DNA sequencing info; de novo transcript meeting; proteogenomics; and rising sequencing applied sciences. the rest chapters from the 1st variation were up to date with the newest details. This ebook additionally offers broad connection with best-practice bioinformatics tools for NGS functions and tutorials for universal workflows. This version addresses the informatics wishes of scholars, laboratory scientists, and computing experts who desire to benefit from the explosion of study possibilities provided by means of new DNA sequencing technologies.
Brian D. Athey
Stuart M. Brown
Gerald A. Higgins
D. Frank Hsu
Guillermo I. Perez-Perez
Kelly V. Ruggles
Phillip Ross Smith
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